Show simple record

dc.contributor.authorHongning, Yin
dc.contributor.authorStewart, Ralph A.
dc.contributor.authorWhalley, Gillian
dc.date.accessioned2015-09-09T02:43:53Z
dc.date.available2015-09-09T02:43:53Z
dc.date.issued2014-04
dc.identifier.issn1443-9506
dc.identifier.urihttps://hdl.handle.net/10652/3017
dc.description.abstractBackground Although mitral regurgitation (MR) results in left ventricular (LV) volume overload, right ventricular (RV) function may also be impaired. We investigated the influence of short-term beta-blockade on RV function in patients with moderate-severe MR. Methods Twenty-six patients were randomised in a cross-over design to receive two weeks of beta-blockade or placebo. Echocardiography was performed at baseline and at the end of the treatment periods. Measure- ments included: RV ejection fraction (RVEF) tricuspid annular motion and Tei index. Results No differences in mean RVEF (64.0 ± 6.0 v 67.0 ± 8.0%, p = 0.3), tricuspid annular motion (13.5 ± 3.0 v 14.7 + 2.9 cm/s, p = 0.5), or median Tei index (0.61 (0.54, 0.88) v 0.59 (0.54, 0.74), p = 0.8) were observed between placebo and metoprolol, despite significantly longer cardiac time intervals. Tei index under both conditions was significantly reduced. Conclusions Short-term treatment with a beta-blocker did not influence RV function in these patients. Interestingly, the RV Tei index was high suggesting significant RV dysfunction despite normal RVEF.en_NZ
dc.language.isoenen_NZ
dc.publisherElsevier Incen_NZ
dc.rights© 2013 Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ)en_NZ
dc.subjectmitral regurgitationen_NZ
dc.subjectbeta-blockersen_NZ
dc.subjectTei indexen_NZ
dc.subjectechocardiographyen_NZ
dc.subjectDoppleren_NZ
dc.titleThe Impact of Beta-blockade on Right Ventricular Function in Mitral Regurgitationen_NZ
dc.typeJournal Articleen_NZ
dc.rights.holderAustralian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ)en_NZ
dc.identifier.doihttp://dx.doi.org/10.1016/j.hlc.2013.10.090en_NZ
dc.subject.marsden110201 Cardiology (incl. Cardiovascular Diseases)en_NZ
dc.identifier.bibliographicCitationHongning, Y., Stewart, R. A., and Whalley, G. A. (2014). The impact of beta-blockade on right ventricular function in mitral regurgitation. Heart, Lung and Circulation, 23, pp.378-380.en_NZ
unitec.institution2nd Hospital of Hebei Medical University, Shijiazhuang, Chinaen_NZ
unitec.institutionAuckland City Hospitalen_NZ
unitec.institutionUnitec Institute of Technologyen_NZ
unitec.publication.spage378en_NZ
unitec.publication.lpage380.en_NZ
unitec.publication.volume23en_NZ
unitec.publication.titleHeart, Lung and Circulation,en_NZ
unitec.peerreviewedyesen_NZ
dc.contributor.affiliationUnitec Institute of Technologyen_NZ
dc.contributor.affiliationHebei Medical Universityen_NZ
dc.contributor.affiliationAuckland City Hospitalen_NZ
unitec.identifier.roms56111en_NZ
unitec.institution.studyareaHealth Sciences


Files in this item

Thumbnail

This item appears in

Show simple record