dc.contributor.author | Hongning, Yin | |
dc.contributor.author | Stewart, Ralph A. | |
dc.contributor.author | Whalley, Gillian | |
dc.date.accessioned | 2015-09-09T02:43:53Z | |
dc.date.available | 2015-09-09T02:43:53Z | |
dc.date.issued | 2014-04 | |
dc.identifier.issn | 1443-9506 | |
dc.identifier.uri | https://hdl.handle.net/10652/3017 | |
dc.description.abstract | Background
Although mitral regurgitation (MR) results in left ventricular (LV) volume overload, right ventricular (RV) function may also be impaired. We investigated the influence of short-term beta-blockade on RV function in patients with moderate-severe MR.
Methods
Twenty-six patients were randomised in a cross-over design to receive two weeks of beta-blockade or placebo. Echocardiography was performed at baseline and at the end of the treatment periods. Measure- ments included: RV ejection fraction (RVEF) tricuspid annular motion and Tei index.
Results
No differences in mean RVEF (64.0 ± 6.0 v 67.0 ± 8.0%, p = 0.3), tricuspid annular motion (13.5 ± 3.0 v 14.7 + 2.9 cm/s, p = 0.5), or median Tei index (0.61 (0.54, 0.88) v 0.59 (0.54, 0.74), p = 0.8) were observed between placebo and metoprolol, despite significantly longer cardiac time intervals. Tei index under both conditions was significantly reduced.
Conclusions
Short-term treatment with a beta-blocker did not influence RV function in these patients. Interestingly, the RV Tei index was high suggesting significant RV dysfunction despite normal RVEF. | en_NZ |
dc.language.iso | en | en_NZ |
dc.publisher | Elsevier Inc | en_NZ |
dc.rights | © 2013 Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ) | en_NZ |
dc.subject | mitral regurgitation | en_NZ |
dc.subject | beta-blockers | en_NZ |
dc.subject | Tei index | en_NZ |
dc.subject | echocardiography | en_NZ |
dc.subject | Doppler | en_NZ |
dc.title | The Impact of Beta-blockade on Right Ventricular Function in Mitral Regurgitation | en_NZ |
dc.type | Journal Article | en_NZ |
dc.rights.holder | Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ) | en_NZ |
dc.identifier.doi | http://dx.doi.org/10.1016/j.hlc.2013.10.090 | en_NZ |
dc.subject.marsden | 110201 Cardiology (incl. Cardiovascular Diseases) | en_NZ |
dc.identifier.bibliographicCitation | Hongning, Y., Stewart, R. A., and Whalley, G. A. (2014). The impact of beta-blockade on right ventricular function in mitral regurgitation. Heart, Lung and Circulation, 23, pp.378-380. | en_NZ |
unitec.institution | 2nd Hospital of Hebei Medical University, Shijiazhuang, China | en_NZ |
unitec.institution | Auckland City Hospital | en_NZ |
unitec.institution | Unitec Institute of Technology | en_NZ |
unitec.publication.spage | 378 | en_NZ |
unitec.publication.lpage | 380. | en_NZ |
unitec.publication.volume | 23 | en_NZ |
unitec.publication.title | Heart, Lung and Circulation, | en_NZ |
unitec.peerreviewed | yes | en_NZ |
dc.contributor.affiliation | Unitec Institute of Technology | en_NZ |
dc.contributor.affiliation | Hebei Medical University | en_NZ |
dc.contributor.affiliation | Auckland City Hospital | en_NZ |
unitec.identifier.roms | 56111 | en_NZ |
unitec.institution.studyarea | Health Sciences | |