dc.contributor.author | Wong, Chih M. | |
dc.contributor.author | Hawkins, Nathaniel M. | |
dc.contributor.author | Petrie, Mark C. | |
dc.contributor.author | Jhund, Pardeep S. | |
dc.contributor.author | Gardner, Roy S. | |
dc.contributor.author | Ariti, Cono A. | |
dc.contributor.author | Poppe, K.K. | |
dc.contributor.author | Earle, Nikki | |
dc.contributor.author | Whalley, Gillian | |
dc.contributor.author | Squire, I.B. | |
dc.contributor.author | Doughty, Robert N. | |
dc.contributor.author | McMurray, John J.V. | |
dc.date.accessioned | 2015-09-10T22:22:10Z | |
dc.date.available | 2015-09-10T22:22:10Z | |
dc.date.issued | 2014-06-17 | |
dc.identifier.issn | 0195-668X | |
dc.identifier.uri | https://hdl.handle.net/10652/3020 | |
dc.description.abstract | Aim
Our understanding of heart failure in younger patients is limited. The Meta-analysis Global Group inChronic Heart Failure (MAGGIC) database, which consisted of 24 prospective observational studies and 7 randomized trials, was used to investigate the clinical characteristics, treatment, and outcomes of younger patients.
Methods and Results
Patients were stratified into six age categories: ,40 (n ¼ 876), 40 – 49 (n ¼ 2638), 50 – 59 (n ¼ 6894), 60 – 69 (n ¼ 12 071), 70 – 79 (n ¼ 13 368), and ≥80 years (n ¼ 6079). Of 41 926 patients, 2.1, 8.4, and 24.8% were younger than 40, 50, and 60 years of age, respectively. Comparing young (,40 years) against elderly (≥80 years), younger patients were more likely to be male (71 vs. 48%) and have idiopathic cardiomyopathy (63 vs. 7%). Younger patients reported better New York Heart Association functional class despite more severe left ventricular dysfunction (median ejection fraction: 31 vs. 42%, all P , 0.0001). Comorbidities such as hypertension, myocardial infarction, and atrial fibrillation were much less common in the young. Younger patients received more disease-modifying pharmacological therapy than their older counterparts. Across the younger age groups (,40, 40 – 49, and 50 – 59 years), mortality rates were low: 1 year 6.7, 6.6, and 7.5%, respectively; 2 year 11.7, 11.5, 13.0%; and 3 years 16.5, 16.2, 18.2%. Furthermore, 1-, 2-, and 3-year mortality rates increased sharply beyond 60 years and were greatest in the elderly (≥80 years): 28.2, 44.5, and 57.2%, respectively.
Conclusion
Younger patients with heart failure have different clinical characteristics including different aetiologies, more severe left ventricular dysfunction, and less severe symptoms. Three-year mortality rates are lower for all age groups under 60 years compared with older patients. | en_NZ |
dc.language.iso | en | en_NZ |
dc.publisher | Oxford University Press on behalf of European Society of Cardiology | en_NZ |
dc.relation.uri | http://eurheartj.oxfordjournals.org/content/ehj/early/2014/06/17/eurheartj.ehu216.full.pdf | en_NZ |
dc.rights | All rights reserved | en_NZ |
dc.subject | heat failure | en_NZ |
dc.subject | younger paitients | en_NZ |
dc.subject | meta-analysis | en_NZ |
dc.title | Heart failure in younger patients: the Meta-analysis Global Group in Chronic Heart Failure (MAGGIC) | en_NZ |
dc.type | Journal Article | en_NZ |
dc.rights.holder | Oxford University Press and the authors | en_NZ |
dc.identifier.doi | doi:10.1093/eurheartj/ehu216 | en_NZ |
dc.subject.marsden | 110201 Cardiology (incl. Cardiovascular Diseases) | en_NZ |
dc.identifier.bibliographicCitation | Wong, C.M., Hawkins, N.M., Petrie, M.C., Jhund, P.S., Gardner, R.S., Ariti, C.A., Poppe, K.K., Earle, N., Whalley, G.A., Squire, I.B., Doughty, R.N., McMurray, J.J.V., and on behalf of the MAGGIC Investigators. (2014). Heart failure in younger patients: the Meta-analysis Global Group in Chronic Heart Failure (MAGGIC). European Heart Journal, 35, pp.2714-2721. NOTE: Available from link below. | en_NZ |
unitec.institution | University of Glasgow, Glasgow, UK | en_NZ |
unitec.institution | Golden Jubilee National Hospital, Glasgow | en_NZ |
unitec.institution | University of British Columbia, Vancouver, BC, Canada | en_NZ |
unitec.institution | London School of Hygiene and Tropical Medicine | en_NZ |
unitec.institution | University of Auckland | en_NZ |
unitec.institution | Unitec Institute of Technology | en_NZ |
unitec.institution | University of Leicester, Leicester, UK | en_NZ |
unitec.publication.spage | 2714 | en_NZ |
unitec.publication.lpage | 2721 | en_NZ |
unitec.publication.volume | 35 | en_NZ |
unitec.publication.title | European Heart Journal | en_NZ |
unitec.peerreviewed | yes | en_NZ |
dc.contributor.affiliation | Unitec Institute of Technology | en_NZ |
dc.contributor.affiliation | University of Glasgow | en_NZ |
dc.contributor.affiliation | Golden Jubilee National Hospital (Clydebank, Scotland) | en_NZ |
dc.contributor.affiliation | University of British Columbia | en_NZ |
dc.contributor.affiliation | London School of Hygiene and Tropical Medicine | en_NZ |
dc.contributor.affiliation | University of Auckland | en_NZ |
dc.contributor.affiliation | University of Leicester | en_NZ |
unitec.identifier.roms | 56941 | en_NZ |
unitec.institution.studyarea | Health Sciences | |