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dc.contributor.authorWong, Chih M.
dc.contributor.authorHawkins, Nathaniel M.
dc.contributor.authorPetrie, Mark C.
dc.contributor.authorJhund, Pardeep S.
dc.contributor.authorGardner, Roy S.
dc.contributor.authorAriti, Cono A.
dc.contributor.authorPoppe, K.K.
dc.contributor.authorEarle, Nikki
dc.contributor.authorWhalley, Gillian
dc.contributor.authorSquire, I.B.
dc.contributor.authorDoughty, Robert N.
dc.contributor.authorMcMurray, John J.V.
dc.date.accessioned2015-09-10T22:22:10Z
dc.date.available2015-09-10T22:22:10Z
dc.date.issued2014-06-17
dc.identifier.issn0195-668X
dc.identifier.urihttps://hdl.handle.net/10652/3020
dc.description.abstractAim Our understanding of heart failure in younger patients is limited. The Meta-analysis Global Group inChronic Heart Failure (MAGGIC) database, which consisted of 24 prospective observational studies and 7 randomized trials, was used to investigate the clinical characteristics, treatment, and outcomes of younger patients. Methods and Results Patients were stratified into six age categories: ,40 (n ¼ 876), 40 – 49 (n ¼ 2638), 50 – 59 (n ¼ 6894), 60 – 69 (n ¼ 12 071), 70 – 79 (n ¼ 13 368), and ≥80 years (n ¼ 6079). Of 41 926 patients, 2.1, 8.4, and 24.8% were younger than 40, 50, and 60 years of age, respectively. Comparing young (,40 years) against elderly (≥80 years), younger patients were more likely to be male (71 vs. 48%) and have idiopathic cardiomyopathy (63 vs. 7%). Younger patients reported better New York Heart Association functional class despite more severe left ventricular dysfunction (median ejection fraction: 31 vs. 42%, all P , 0.0001). Comorbidities such as hypertension, myocardial infarction, and atrial fibrillation were much less common in the young. Younger patients received more disease-modifying pharmacological therapy than their older counterparts. Across the younger age groups (,40, 40 – 49, and 50 – 59 years), mortality rates were low: 1 year 6.7, 6.6, and 7.5%, respectively; 2 year 11.7, 11.5, 13.0%; and 3 years 16.5, 16.2, 18.2%. Furthermore, 1-, 2-, and 3-year mortality rates increased sharply beyond 60 years and were greatest in the elderly (≥80 years): 28.2, 44.5, and 57.2%, respectively. Conclusion Younger patients with heart failure have different clinical characteristics including different aetiologies, more severe left ventricular dysfunction, and less severe symptoms. Three-year mortality rates are lower for all age groups under 60 years compared with older patients.en_NZ
dc.language.isoenen_NZ
dc.publisherOxford University Press on behalf of European Society of Cardiologyen_NZ
dc.relation.urihttp://eurheartj.oxfordjournals.org/content/ehj/early/2014/06/17/eurheartj.ehu216.full.pdfen_NZ
dc.rightsAll rights reserveden_NZ
dc.subjectheat failureen_NZ
dc.subjectyounger paitientsen_NZ
dc.subjectmeta-analysisen_NZ
dc.titleHeart failure in younger patients: the Meta-analysis Global Group in Chronic Heart Failure (MAGGIC)en_NZ
dc.typeJournal Articleen_NZ
dc.rights.holderOxford University Press and the authorsen_NZ
dc.identifier.doidoi:10.1093/eurheartj/ehu216en_NZ
dc.subject.marsden110201 Cardiology (incl. Cardiovascular Diseases)en_NZ
dc.identifier.bibliographicCitationWong, C.M., Hawkins, N.M., Petrie, M.C., Jhund, P.S., Gardner, R.S., Ariti, C.A., Poppe, K.K., Earle, N., Whalley, G.A., Squire, I.B., Doughty, R.N., McMurray, J.J.V., and on behalf of the MAGGIC Investigators. (2014). Heart failure in younger patients: the Meta-analysis Global Group in Chronic Heart Failure (MAGGIC). European Heart Journal, 35, pp.2714-2721. NOTE: Available from link below.en_NZ
unitec.institutionUniversity of Glasgow, Glasgow, UKen_NZ
unitec.institutionGolden Jubilee National Hospital, Glasgowen_NZ
unitec.institutionUniversity of British Columbia, Vancouver, BC, Canadaen_NZ
unitec.institutionLondon School of Hygiene and Tropical Medicineen_NZ
unitec.institutionUniversity of Aucklanden_NZ
unitec.institutionUnitec Institute of Technologyen_NZ
unitec.institutionUniversity of Leicester, Leicester, UKen_NZ
unitec.publication.spage2714en_NZ
unitec.publication.lpage2721en_NZ
unitec.publication.volume35en_NZ
unitec.publication.titleEuropean Heart Journalen_NZ
unitec.peerreviewedyesen_NZ
dc.contributor.affiliationUnitec Institute of Technologyen_NZ
dc.contributor.affiliationUniversity of Glasgowen_NZ
dc.contributor.affiliationGolden Jubilee National Hospital (Clydebank, Scotland)en_NZ
dc.contributor.affiliationUniversity of British Columbiaen_NZ
dc.contributor.affiliationLondon School of Hygiene and Tropical Medicineen_NZ
dc.contributor.affiliationUniversity of Aucklanden_NZ
dc.contributor.affiliationUniversity of Leicesteren_NZ
unitec.identifier.roms56941en_NZ
unitec.institution.studyareaHealth Sciences


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