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dc.contributor.authorJackson, Colette E.
dc.contributor.authorCastagno, Davide
dc.contributor.authorMaggioni, A.P.
dc.contributor.authorKøber, Lars
dc.contributor.authorSquire, I.B.
dc.contributor.authorSwedberg, Karl
dc.contributor.authorAndersson, Bert
dc.contributor.authorRichards, A.M.
dc.contributor.authorBayes-Genis, Antoni
dc.contributor.authorTribouilloy, Christophe
dc.contributor.authorDobson, Joanna
dc.contributor.authorAriti, Cono A.
dc.contributor.authorPoppe, K.K.
dc.contributor.authorEarle, Nikki
dc.contributor.authorWhalley, Gillian
dc.contributor.authorPocock, Stuart J.
dc.contributor.authorDoughty, Robert N.
dc.contributor.authorMcMurray, John J.V.
dc.description.abstractAIMS: Low pulse pressure is a marker of adverse outcome in patients with heart failure (HF) and reduced ejection fraction (HFREF) but the prognostic value of pulse pressure in patients with HF and preserved ejection fraction (HF-PEF) is unknown. We examined the prognostic value of pulse pressure in patients with HF-PEF [ejection fraction (EF) ≥ 50%] and HF-REF. METHODS AND RESULTS: Data from 22 HF studies were examined. Preserved left ventricular ejection fraction (LVEF) was defined as LVEF ≥ 50%. All-cause mortality at 3 years was evaluated in 27 046 patients: 22 038 with HF-REF (4980 deaths) and 5008 with HFPEF (828 deaths). Pulse pressure was analysed in quintiles in a multivariable model adjusted for the previously reported Meta-Analysis Global Group in Chronic Heart Failure prognostic variables. Heart failure and reduced ejection fraction patients in the lowest pulse pressure quintile had the highest crude and adjusted mortality risk (adjusted hazard ratio 1.68, 95% confidence interval 1.53–1.84) compared with all other pulse pressure groups. For patients with HF-PEF, higher pulse pressure was associated with the highest crude mortality, a gradient that was eliminated after adjustment for other prognostic variables. CONCLUSION: Lower pulse pressure (especially ,53 mmHg) was an independent predictor of mortality in patients with HF-REF, particularly in those with an LVEF , 30% and systolic blood pressure ,140 mmHg. Overall, this relationship between pulse pressure and outcome was not consistently observed among patients with HF-PEF.en_NZ
dc.publisherEuropean Society of Cardiologyen_NZ
dc.rightsAll rights reserveden_NZ
dc.subjectpulse pressureen_NZ
dc.subjectheart failureen_NZ
dc.subjectreduced ejection fractionen_NZ
dc.subjectpreserved ejection fractionen_NZ
dc.subjectMeta-Analysis Global Group in Chronic Heart Failure (MAGGIC)en_NZ
dc.titleDiffering prognostic value of pulse pressure in patients with heart failure with reduced or preserved ejection fraction: results from the MAGGIC individual patient meta-analysisen_NZ
dc.typeJournal Articleen_NZ
dc.rights.holderEuropean Society of Cardiologyen_NZ
dc.subject.marsden110201 Cardiology (incl. Cardiovascular Diseases)en_NZ
dc.identifier.bibliographicCitationJackson, C.E., Castagno, D., Maggioni, Aldo P., Køber, L., Squire, I.B., Swedburg, K., Anderssonn, B., Richards, M.A., Bayes-Genis, Tribouilloy, C., Dobson, J., Airiti, Cono A., Poppe, K.K., Earle, N., Whalley, G., Pocock, S.J., Doughty, R.N., and McMurray, J.J.V. doi:10.1093/eurheartj/ehu490en_NZ
unitec.institutionUniversity of Glasgow (Scotland)en_NZ
unitec.institutionUniversity of Turin (Torino, Italy)en_NZ
unitec.institutionAssociazione Nazionale Medici Cardiologi Ospedalieri Research Center (Florence, Italy)en_NZ
unitec.institutionRigshospitalet-Copenhagen University Hospital (Copenhagen, Denmark)en_NZ
unitec.institutionGlenfield Hospital (Leicester, UK)en_NZ
unitec.institutionUniversity of Gothenburg (Sweden)en_NZ
unitec.institutionUniversity of Otago (Christchurch, New Zealand)en_NZ
unitec.institutionNational University Heart Centre (Singapore)en_NZ
unitec.institutionHospital Universitari Germans Trias i Pujol (Badalona, Spain)en_NZ
unitec.institutionUniversity Hospital Amiens (France)en_NZ
unitec.institutionJules Verne University of Picardie (Amiens, France)en_NZ
unitec.institutionLondon School of Hygiene and Tropical Medicineen_NZ
unitec.institutionUniversity of Aucklanden_NZ
unitec.institutionUnitec Institute of Technologyen_NZ
unitec.publication.volumeOnline (23 January)en_NZ
unitec.publication.titleEuropean Heart Journalen_NZ
dc.contributor.affiliationUnitec Institute of Technologyen_NZ
dc.contributor.affiliationUniversity of Glasgowen_NZ
dc.contributor.affiliationUniversity of Turinen_NZ
dc.contributor.affiliationRigshospitalet (Copenhagen, Denmark)en_NZ
dc.contributor.affiliationUniversity of Leicesteren_NZ
dc.contributor.affiliationNational Heart and Lung Instituteen_NZ
dc.contributor.affiliationUniversity of Gothenburgen_NZ
dc.contributor.affiliationUniversity of Otagoen_NZ
dc.contributor.affiliationNational University Heart Centre (Singapore)en_NZ
dc.contributor.affiliationHospital Universitari Germans Trias i Pujol (Badalona, Spain)en_NZ
dc.contributor.affiliationUniversity Hospital Amiens (France)en_NZ
dc.contributor.affiliationJules Verne University of Picardie (Amiens,France)en_NZ
dc.contributor.affiliationLondon School of Hygiene and Tropical Medicineen_NZ
dc.contributor.affiliationUniversity of Aucklanden_NZ
unitec.institution.studyareaHealth Sciences

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